Apigen is a plant compound derived from Chinese medicine for antibacterial, anti-inflammatory, and antiviral uses.
Apigen is found in celery and celery juice. The juice also provides luteolin, a flavonoid with anti-cancer properties.
In recent years interest in apigenin as a beneficial and health-promoting agent has grown.
Apigenin promotes different anti-inflammatory pathways, including p38/MAPK and PI3K/Akt, as well as prevent the IKB degradation and nuclear translocation of the NF-κB and reduce COX-2 activity.
After absorption into the digestive tract, apigenin can reach the brain through the circulatory system, crossing the blood-brain barrier before exerting its affinity with the GABAA-receptor and acting on the CNS, despite its action at the level of improving the clinical use of benzodiazepines is not clear.
Reference: The Therapeutic Potential of Apigenin